SCI09018 2023 Delivery Systems and Tissue Engineering Products

General Details

Full Title
Delivery Systems and Tissue Engineering Products
Transcript Title
Delivery and Tissue Engineeing
Code
SCI09018
Attendance
N/A %
Subject Area
SCI - Science
Department
LIFE - Life Sciences
Level
09 - NFQ Level 9
Credit
05 - 05 Credits
Duration
Semester
Fee
Start Term
2023 - Full Academic Year 2023-24
End Term
9999 - The End of Time
Author(s)
Ailish Breen
Programme Membership
SG_SATMP_S09 202300 Postgraduate Certificate in Advanced Therapy Medicinal Products (ATMP) Vector Manufacturing SG_SATMQ_M09 202300 Master of Science in Advanced Therapy Medicinal Products (ATMP) Vector Manufacturing SG_SATMP_O09 202300 Postgraduate Diploma in Science in Advanced Therapy Medicinal Products (ATMP) Technology and Manufacturing SG_SATMP_M09 202300 Master of Science in Advanced Therapy Medicinal Products (ATMP) Technology and Manufacturing
Description

This module is an introduction to the interdisciplinary field of tissue engineering and regenerative medicine using delivery systems. Essentially, new and functional living tissue can be fabricated by delivering cells, scaffolds, DNA and/or proteins at surgery. This course will introduce advances in the fields of material science, regenerative medicine and their relationship towards developing novel "cell, gene and tissue engineered" therapies.

Learning Outcomes

On completion of this module the learner will/should be able to;

1.

Evaluate established and emerging natural and synthetic biomaterials for their uses in cell / gene delivery and as tissue engineering scaffolds

2.

Compare efficacy of new and emerging polymer systems for gene and cell delivery, such as nanoparticles, lipid based systems, glycopolymers, smart polymers etc

3.

Describe and analyse tissue engineered scaffold fabrication methods, and evaluate the role of bioreactors in cell / scaffold development

4.

Demonstrate an appreciation of preclinical and clinical testing requirement and suggest suitable in vitro and in vivo test methods

5.

Formulate hypotheses to treat existing clinical problems that would benefit from targeted delivery / tissue engineering approach and evaluate associated sustainability and ethical concerns

Teaching and Learning Strategies

A virtual learning environment (e.g. Moodle) will be used as a repository of educational resources and as a means of assessment. Self‑directed, student‑centred, independent learning is a core aspect through completion of module coursework.

Module Assessment Strategies

The assessment approach for this module will be 100% Continuous Assessment with a range of assessment methods employed including some of the following: short-form assessment exams incl. MCQ's, project assignments, essays, oral presentations, vivas etc. The major element of assessment will take an evidence based approach to evaluating current literature and proposing / defending new theories and hypotheses.

Repeat Assessments

Repeat continuous assessment of the failed elements in line with marks and standards

Indicative Syllabus

1. Evaluate established and emerging natural and synthetic biomaterials for their uses in cell / gene delivery and as tissue engineering scaffolds

  • Biomaterial selection - synthetic and natural materials suitable for in vivo delivery
  • Scaffolds suitable for tissue engineering, biological and mechanical properties

2. Compare efficacy of new and emerging polymer systems for gene and cell delivery, such as nanoparticles, lipid based systems, glycopolymers, smart polymers etc

  • Polymer-based, lipid-based methods of gene / cell / drug delivery including nanoparticle encapsulation, pH / thermo responsive polymers etc.

3. Describe and analyse tissue engineered scaffold fabrication methods, and evaluate the role of bioreactors in cell / scaffold development

Scaffold-guided tissue generation – current scaffold fabrication techniques including electrospinning, 3D printing and Bioprinting etc. and use of ‘sustainable' fabrication techniques.

  • Material characterisation in vitro
  • Types of bioreactors and their role in tissue engineering: perfusion, rotating wall, spinner etc.

4. Demonstrate an appreciation of preclinical and clinical testing requirement and suggest suitable in vitro and in vivo test methods

  • Biocompatibility requirements in vitro, in vivo test methods and characterisation of in vivo studies

5. Formulate hypotheses to treat existing clinical problems that would benefit from targeted delivery / tissue engineering approach and evaluate associated ethical concerns

  • Future of tissue engineering / regenerative medicine and nucleic acid delivery.
  • Review of ethical considerations for the development of these products

 

 

 

Coursework & Assessment Breakdown

Coursework & Continuous Assessment
100 %

Coursework Assessment

Title Type Form Percent Week Learning Outcomes Assessed
1 MCQ/SAQ/LAQ Coursework Assessment Assessment 20 % Week 6 1,2,3
2 Case study Coursework Assessment Assessment 30 % Week 9 4
3 Group work and presentation Project Assessment 50 % Week 13 5

Online Learning Mode Workload


Type Location Description Hours Frequency Avg Workload
Lecture Online Lecture 2 Weekly 2.00
Independent Learning Not Specified Directed and Independent Learning 4 Weekly 4.00
Total Online Learning Average Weekly Learner Contact Time 2.00 Hours

Required & Recommended Book List

Recommended Reading
2020-12-18 Biomaterials for Cell Delivery CRC Press
ISBN 0367732335 ISBN-13 9780367732332

The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets. Key selling features: Describes developing cell/biomaterial constructs for regenerative medicine Reviews state-of-the-art of biomaterial carriers Summarizes the unique problems associated with key tissue and organ targets Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models

Required Reading
2013 Biomaterials Science Academic Press
ISBN 0123746264 ISBN-13 9780123746269

With over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials Edited by four of the best-known figures in the biomaterials field today and fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include: tissue engineering, drug delivery systems, new materials, and new clinical applications New teaching and learning material includes: end of chapter exercises, case studies, downloadable image bank This new edition is printed in full-color with high-quality artwork The third edition of this renowned and best-selling title is the most comprehensive and up-to-date single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials, and acts as a key reference for practitioners who have involvement in the applications of materials in medicine. This resource is ideal for undergraduate and graduate students, practitioners in biomedical engineering, life and biological sciences, materials, mechanical and engineering sciences, and medicine. Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: 'the only such text that currently covers this area comprehensively' - Materials Today Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, end of chapter exercises, assignments and case studies; and a downloadable image bank. The new edition is printed in full color throughout, with new high-quality artwork

Module Resources

Non ISBN Literary Resources
Updated Literary Resources
Journal Resources

Students will be directed to read relevant journal articles from the journal Science, Cell, Gene therapy, Biomaterials, Tissue Engineering, etc. as appropriate

URL Resources

European Medicines Agency - Clinical aspects related to tissue engineered products - Scientific guideline

https://www.ema.europa.eu/en/clinical-aspects-related-tissue-engineered-products-scientific-guideline

Other Resources
Additional Information