PHRM07021 2020 Active Ingredient Synthesis

Demonstrate competence in the application of a range of organic chemical synthetic techniques to the production of some common active pharmaceutical ingredients.

Determine quantities of starting materials as well as relevant glassware and equipment required for each synthesis.

Generate and follow Standard Operating Procedures (SOPs) in the use of some standard laboratory equipment.

While working as a member of a group, evaluate the risks associated with each synthetic method and understand how to mitigate against these risks.

Record and report on the synthetic method, including any deviations or variations to the process.

This module will be delivered to online. This will include lectures and laboratory practicals augmented by independent learning and directed learning. Attendance at a workshop to complete the laboratory practicals is mandatory. Exemption from attending the workshop may be considered where a student can demonstrate that the learning outcomes of the practicals can be achieved through a work-based project. Moodle will be used as a repository of educational resources and as a means of assessment (e.g. quizzes, uploading assignments and journals).

This module is 65% continuous assessment and 35% final exam.

Students will be assessed using Moodle based multiple choice and short answer questions, laboratory performance and results, and reinforced with a final written examination.

Repeat Continuous Assessment and/or Final Exam.

This module encompasses API synthesis. Practical sessions will include:

• Generation of Standard Operating Procedures (SOPs)
• Active Pharmaceutical Ingredient (API) Synthesis

Emphasis throughout is on awareness of GMP / GLP requirements in a pharmaceutical environment.