PHRM07012 2019 ACTIVE INGREDIENT SYNTHESIS

Demonstrate competence in the application of a range of organic chemical synthetic techniques to the production of some common active pharmaceutical ingredients.

Analyse some standard synthetic methods and use these to  generate manufacturing documentation in line with cGMP.

Determine quantities of starting materials as well as relevant glassware and equipment required for each synthesis

Generate and follow Standard Operating Procedures (SOP's) in the use of some standard laboratory equipment . 

 Record and report on the synthetic method, including any deviations or variations to the process. 

While working as a member of a group, evaluate the risks associated with each synthetic method and understand how to mitigate against these risks

This module will be delivered full-time. It will consist of a series of laboratory practicals culminating in the synthesis of selected API's.

Moodle will be used as a repository of educational resources.

Students will be assessed based on laboratory performance and results. Further assessment methods include a series of pre- and post laboratory assessments as well as Moodle based multiple choice and short answer questions.

Students may repeat Continuous Assessment as required

This module encompasses  API synthesis

Practical sessions will include,

Generation of Standard Operating Procedures (SOP's)

Active Pharmaceutical Ingredient (API) synthesis

Emphasis throughout is on awareness of GMP / GLP requirements in a pharmaceutical environment.