PHAR06002 2019 Medical Pharmacology

Gain a thorough understanding of Pharmacodynamics, the basic principles underlying drug action in the mammalian body and the Pharmacokinetics effect of the body on the drug molecule.

Describe the endocrine, nervous and excretory systems and the mechanisms of drug interaction with these systems.

Detail the MOA of Diuretics and Drugs Affecting Renal Function, Cardiovascular and Respiratory Pharmacology.

Describe the key factors involved in drug-receptor interaction and intracellular signalling mechanisms.

Detail the methods of Chemotherapy and modes of activity/selectivity, Structure Activity Relationship, Describe the mechanisms of transfer and of manipulation of the genetic elements involved in antibiotic resistance.

This module will be delivered full‑time. This module will include a 2 hour lecture and a 1.5 hour computer workshop session weekly augmented by independent learning and directed learning. This approach is expected to address student learning needs. moodle will be used as a repository of educational resources and as a means of assessment (quizzes).

This module has a final exam worth 60% and a continuous assessment element worth 40%.

CA will consist of ongoing short answer questions and multiple choice quizzes.

Repeat Continuous Assessment and/or Final Exam.

1. Gain a thorough understanding of Pharmacodynamics, the basic principles underlying drug action in the mammalian body and the Pharmacokinetics effect of the body on the drug molecule.

• General Principles Introduction, ADME and Definition of Terms, Pharmacokinetics, Pharmacodynamics ‑ Relationship of Distributional Factors and Protein Binding, to Concentration of Drug at the Receptor Site, Pharmacogenetics/genomics, Principles of Drug Interactions, Development, Evaluation and Control of Drugs

 2. Describe the endocrine, nervous and excretory systems and the mechanisms of drug interaction with these systems.

• Cardiovascular and Respiratory Pharmacology. Review of Cardiovascular Physiology, Drugs Used for Cardiac and Cardiovascular Therapy. Anti‑Arrhythmic Agents ‑ Introduction to Cardiac Electrophysiology, Pharmacological Agents, Management of Acute and Chronic Heart Failure, Antihypertensive and Related medicines, AntiAnginal Drugs
• Diuretics and Drugs Affecting Renal Function, Water, and Electrolyte Metabolism. Review of Renal Physiology/Biochemistry, Diuretics, Agents Affecting the Renal Conservation of Water.
• Gastrointestinal Drugs. Drugs for the Treatment of Peptic Ulcer Disease, Secretory Drugs, Prokinetic Drugs, Laxative Drugs

3. Detail the MOA of Diuretics and Drugs Affecting Renal Function, Cardiovascular and Respiratory Pharmacology.

•  Endocrine Pharmacology. Hypothalamus, Anterior and Posterior Pituitary, Adrenal Cortex‑ Glucocorticoids/related drugs Mineralocorticoids/related drugs, Gonads, Estrogens/Progestins/related drugs, Androgens/related drugs, Thyroid, mechanisms by which thyroid hormones regulate cellular function, Pancreas/related Drugs, insulin secretion mechanism.

4. Describe the key factors involved in drug‑receptor interaction and intracellular signalling mechanisms

•  Introduction to the autonomic nervous system, Cholinergic neurotransmission and muscarinic agonists, Anticholinesterase, Antagonists at muscarinic receptor sites, , Drugs acting at autonomic ganglia, Antagonists at nicotinic receptor sites in the skeletal neuromuscular junction, Sympathetic neurotransmission, and the adrenal medulla, Indirectly acting sympathomimetic agents,
• Drugs Acting on the Central Nervous System. Neurotransmitters, Neuromodulators, and Receptors, General Anaesthetics, Local Anaesthetics, Opioid Analgesics, Agonist antagonists, medicines Used in the Treatment of Motor Disorders, Antiepileptics

5. Detail the methods of Chemotherapy and modes of activity/selectivity, Structure Activity

• Relationship, Describe the mechanisms of transfer and of manipulation of the genetic elements involved in antibiotic resistance.
• Chemotherapy. Introduction of chemotherapy, Sulfonamides and DNA gyrase inhibitors, Inhibitors of Cell Wall Synthesis, Inhibitors of protein synthesis, Antimycobacterial Drugs, Antifungal Agents, Antiviral Drugs, Antiparasitic Drugs, Anticancer Drugs, immunomodulators.

6. Demonstrate research techniques for obtaining drug information from drug references and other sources

• Clinical Trials