BIO08037 2019 BIOPHARMACEUTICAL SCIENCE PRACTICAL
This Biopharma laboratory practical module will provide students with practical knowledge, know-how and practical skills associated with biopharmaceutical operations. The relevant learning is achieved through the completion of a sequence of laboratory-based and pilot-plant based practicals and experiments that are designed to impart the required expertise. There will also be some research project work associated with the laboratory practicals.
On completion of this module the learner will/should be able to;
Demonstrate a range of practical knowledge and skills associated with upstream bioprocessing operations
Demonstrate a range of practical knowledge and skills associated downstream bioprocessing operations.
Demonstrate a range of practical knowledge and skills associated with aseptic processing and filling operations
Perform project work related to the practical sessions
Evaluate the data and results obtained from the practical sessions
Demonstrate effective communication skills in a written format.
Teaching and Learning Strategies
Module Assessment Strategies
The assessment strategy will comprise of both observation of skills being acquired as well as formal assessment of knowledge acquisition. There will be a project research element associated with the assessment strategy also.
The miniproject is a MANDATORY form of assessment for any modules on this programme with a miniproject component.
The range of lab-based and pilot plant-based practical sessions may include some or all of the following:
- Facility Tour - overview of all aspects of the bioprocess – upstream, harvest, downstream and fill finish, along with associated services such as buffer prep, media prep, and clean utilities that service the plant.
- Cell Culture Processing - aseptic technique, cell culturing, cell sampling, counting and substrate analysis.
- Downstream Processing - protein concentration using ultrafiltration and buffer exchange using diafiltration.
- Aseptic Procssing - contamination control, filling line operation and glove integrity testing.
Coursework & Assessment Breakdown
|Title||Type||Form||Percent||Week||Learning Outcomes Assessed|
|1||Closed Book Exam Exam at end of day 3 of lab. practicals.||Coursework Assessment||Closed Book Exam||40 %||Week 7||1,2,3|
|2||Project Research project based around the lab. practicals.||Coursework Assessment||Project||60 %||Week 10||4,5,6|
Part Time Mode Workload
|Practical / Laboratory||Science Laboratory||Attendance at laboratory practicals.||22||Once Per Semester||1.47|
|Independent Learning||UNKNOWN||Research project based on lab. practicals.||3||Weekly||3.00|
Walsh, Gary. 'Pharmaceutical Biotechnology'. Wiley. 2007.:-:-#160:::::-:-#160::::
Ratledge, Colin and Kristiansen Bjorn. 'Basic Biotechnology'. Cambridge Press. 2001.
Doran, Pauline M. 'Bioprocess Engineering Principles'. Academic Press. 1995.
Hatti-Kaul, Rajni and Mattiasson, Bo. 'Isolation and Purification of Proteins'. Marcel-Dekker. 2003.:-:-#160::::
as per moodle page
as per moodle page