BIO07022 2019 PROTEIN BIOTECHNOLOGY
This module aims to study the structure and function of proteins in greater depth than the basics covered in a Biochemistry module. Protein primary, secondary, tertiary and quaternary structure will be examined using non traditional methods.. There is a heavy emphasis on using bioinformatics and data mining technologies to gain an understanding of protein design and genetic manipulation.
On completion of this module the learner will/should be able to;
List and explain the major bond types which accompany peptide and protein formation and understand what conditions need to be maintained to preserve their structure.
Illustrate and distinguish between the main secondary, tertiary and quaternary structures which are formed during protein synthesis and also the role and significance of post translational modifications.
Examine the key functions of proteins in cells and tissues and the characterize the role of proteins in human disease.
Demonstrate an ability to search and compare DNA and protein sequences and structures from sequencing databases using data mining techniques.
Demonstrate an ability to write industry standard reports with particular emphasis on effective referencing and prioritisiation/selection of relevant material.
Teaching and Learning Strategies
'This module will be delivered fulltime. This will include lectures and computer laboratory practicals augmented by independent learning and directed learning. This approach is expected to address student learning needs. Moodle will be used as a repository of educational resources and as a means of assessment (e.g. quizzes, uploading assignments and journals).
Module Assessment Strategies
This module is 100% Continuous Assessment. There will be 3 number of MCQs given during the semester every four weeks. A written summary of a chosen peer reviewed article on protein will be submitted at the end of the semester. A project on a specific recombinant protein is submitted at the end of the semester which demonstrates the student's ability to critically evaluate an aspect of recombinant protein design and production.
Repeat Continuous Assessment and/or project resubmission.
Protein adverse reactions
Protein Functions and protein as drugs
Proteins and Disease
Coursework & Assessment Breakdown
|Title||Type||Form||Percent||Week||Learning Outcomes Assessed|
|1||Theory quizzes.||Coursework Assessment||Multiple Choice/Short Answer Test||45 %||Any||1,2,3|
|2||Group Project Group \Discussion of Protein Relevant Topics||Formative||Group Project||- %||Any||1,2,3,4,5|
|3||Literature Survey||Coursework Assessment||Written Report/Essay||15 %||End of Semester||4,5|
|4||Individual Project Topical Individual Research||Project||Written Report/Essay||40 %||End of Semester||1,2,3,4,5|
Full Time Mode Workload
|Independent Learning||Not Specified||Self Study||5||Weekly||5.00|
Required & Recommended Book List
2016 Introduction to Protein Science Oxford University Press, USA
ISBN 0198716842 ISBN-13 9780198716846
Proteins are essential to life, having a vital role in all living organisms. They are the ultimate micro machines: some are building blocks, joining with other substances to make the cells from which we are all formed. Some are catalysts, speeding up essential biochemical reactions to keep our cells alive. Yet others help cells to communicate, to move, and to build up the complex mix of tissues that make up our bodies. Introduction to Protein Science provides a broad ranging introduction to the contemporary study of proteins suitable for students on biosciences degrees internationally. Starting by describing the structure of proteins and how these structures can be studied, the book goes on to illustrate the wide range of functions that proteins have, showing how the shape of a protein is intimately linked to the function that it has. The book then describes how new experimental and computational techniques are helping us to predict a protein s structure and function, and how this is paving the way for us to design new proteins with specific characteristics, with exciting implications in areas such as drug design. Written by Arthur Lesk, the author of the highly successful Introduc
Introduction to protein science: Architecture, function and genomics. Arthur M.Lesk. Oxford University Press 1st ed. 2004
Protein Biochemistry and Proteomics, Hubert Rehm. Oxford University Press 2006