BIO06011 2019 Upstream Bioprocessing
Full Title
Upstream Bioprocessing
Transcript Title
Upstream Bioprocessing
Code
BIO06011
Attendance
N/A %
Subject Area
BIO - Bio Tech/Eng/Chem
Department
LIFE - Life Sciences
Level
06 - NFQ Level 6
Credit
10 - 10 Credits
Duration
Semester
Fee
€
Start Term
2019 - Full Academic Year 2019-20
End Term
9999 - The End of Time
Author(s)
Stephen Daly
Programme Membership
SG_SBIOP_E06 201900 Certificate in Biopharmaceutical Processing.
SG_SGOOD_C06 202300 Higher Certificate in Science in Good Manufacturing Practice and Technology
SG_SGOOD_C06 202300 Higher Certificate in Science in Good Manufacturing Practice & Technology
Description
This module aims to provide the student with a fundamental understanding of both the theory and practical aspects of cell culture processing as it pertains to the manufacture of modern biopharmaceutical products.
Learning Outcomes
On completion of this module the learner will/should be able to;
1.
Describe cell biology
2.
List the different types of cells that can be used in biopharmaceutical manufacturing and their advantages and disadvantages.
3.
Describe how cells produce protein.
4.
Explain cell growth kinetics and scale up.
5.
Describe and perform cell counting.
6.
List and discuss the equipment used in a cell culture facility
7.
Discuss and identify bioreactor features.
8.
Explain bioreactor control.
Teaching and Learning Strategies
This module will be delivered part time. It will include lectures and Laboratory practical augmented by independent learning. Moodle will be used as a repository of educational resources and as a means of assessment.
Module Assessment Strategies
This module is 70% continuous assessment and 30% final exam. A combination of multiple choice questions and a project will be used as part of the continuous assessment.
Repeat Assessments
Repeat continuous assessment and/or final exam.
Module Dependencies
Prerequisites
None
Co-requisites
None
Incompatibles
None
Indicative Syllabus
The following is an indicative summary of the main topics included in this module:
- Introduction to cell biology.
- Cell protein synthesis.
- Cell culture and counting.
- Cell culture equipment.
- Cell growth and sub-culturing.
- Features of a bioreactor.
- Bioreactor scale-up.
- Types of bioreactor.
Coursework & Assessment Breakdown
Coursework & Continuous Assessment
70 %
End of Semester / Year Formal Exam
30 %
Coursework Assessment
| Title | Type | Form | Percent | Week | Learning Outcomes Assessed | |
|---|---|---|---|---|---|---|
| 1 | MCQ 1 | Coursework Assessment | Multiple Choice/Short Answer Test | 15 % | Week 6 | 1,2,3,4 |
| 2 | MCQ 2 | Coursework Assessment | Multiple Choice/Short Answer Test | 15 % | Week 13 | 5,6,7,8 |
| 3 | Lap Report | Coursework Assessment | Assignment | 40 % | Week 9 | 4,6,7,8 |
End of Semester / Year Assessment
| Title | Type | Form | Percent | Week | Learning Outcomes Assessed | |
|---|---|---|---|---|---|---|
| 1 | Final exam | Final Exam | Closed Book Exam | 30 % | End of Semester | 1,2,3,4,5,6,7,8 |
Part Time Mode Workload
| Type | Location | Description | Hours | Frequency | Avg Workload |
|---|---|---|---|---|---|
| Lecture | Distance Learning Suite | Online lecture. | 2 | Weekly | 2.00 |
| Practical / Laboratory | Science Laboratory | Lab. practical experiments. | 20 | Once Per Semester | 1.33 |
| Directed Learning | Not Specified | Directed self-study. | 5 | Weekly | 5.00 |
Total Part Time Average Weekly Learner Contact Time 8.33 Hours
Module Resources
Non ISBN Literary Resources
‘Pharmaceutical Biotechnology - Concepts and Applications' by Gary Walsh.
Wiley Publications. 2007. ISBN - 978-0-470-01244-4.
‘Basic Biotechnology' by Colin Ratledge and Bjorn Kristiansen.
Cambridge Press. 2001. ISBN - 0-521-779170.
Other Resources
None
Additional Information
None